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Wikipedia - 5-alpha-reductase inhibitor

5a-Reductase inhibitors (or 5-alpha-reductase inhibitors) are a group of drugs with antiandrogenic activity, used in the treatment of benign prostatic hyperplasia and androgenic (or androgenetic) alopecia. These drugs decrease the levels of available 5a-reductase prior to testosterone's binding with the enzyme, thus reducing levels of dihydrotestosterone that derives from such a bond.

Contents

[edit] Clinical use

[edit] Indications

5a-Reductase inhibitors are clinically used in the treatment of conditions that are exacerbated by dihydrotestosterone. To be specific, these indications may include:[1]

[edit] Adverse drug reactions

In general, adverse drug reactions (ADRs) experienced with 5a-reductase inhibitors are dose-dependent. Common ADRs include impotence, decreased libido, and decreased ejaculate volume. Rare ADRs include breast tenderness and enlargement, and allergic reaction.[1]

[edit] Pharmacology

The enzyme 5a-reductase is involved in the conversion of testosterone to the active form dihydrotestosterone by reducing the ?4,5 double-bond. In benign prostatic hyperplasia, dihydrotestosterone acts as a potent cellular androgen and promotes prostate growth; therefore, inhibiting the enzyme reduces the excessive prostate growth. In alopecia, male-pattern baldness is one of the effects of androgenic receptor activation. Thus, reducing the levels of dihydrotestosterone reduces alopecia.

Results of an enzyme assay conducted with an extract of Ganoderma lucidum (Reishi) and the enzyme 5-alpha reductase.[2]

Some compounds in nature are able to inhibit 5a-reductase, like the Reishi mushroom[2]

[edit] Examples

[edit] References

  1. ^ a b Rossi S (Ed.) (2004). Australian Medicines Handbook 2004. Adelaide: Australian Medicines Handbook. ISBN 0-9578521-4-2
  2. ^ a b Liu J, Kurashiki K, Shimizu K, Kondo R (February 2006). "5alpha-reductase inhibitory effect of triterpenoids isolated from Ganoderma lucidum". Biol. Pharm. Bull. 29 (2): 392–5. doi:10.1248/bpb.29.392. PMID 16462054. 
v • d • e
Pharmacology: enzyme inhibition
Class
Substrate
Hydrolase (EC 3)
Lyase (EC 4)
v • d • e
Drugs used in benign prostatic hypertrophy (G04C)
5a-reductase inhibitors
Alpha blockers (a1)
Herbals
Retrieved from "http://en.wikipedia.org/wiki/5-alpha-reductase_inhibitor"

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "5-alpha-reductase inhibitor".

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